Tafinlar

Drug List

Tafinlar

Drug Name

Tafinlar (Dabrafenib mesylate)

Manufactured By

Novartis Pharmaceuticals Corporation

Drug Savings

NPC's mission is your health. We recognize your need for help when you are applying for discount programs for your prescription medications. We consist of friendly and experienced advocates that not only know how these free and discount programs work, but are ready to help. We are available to take your call and answer any questions you may have as you search for the right program to fit your needs. We can also explain any supporting material you may need to provide as you apply for these programs. If for any reason you are denied, we also are experienced in the best appeals process with a high success rate.

NPC's mission is your health. We recognize your need for help when you are applying for discount programs for your prescription medications. We consist of friendly and experienced advocates that not only know how these free and discount programs work, but are ready to help. We are available to take your call and answer any questions you may have as you search for the right program to fit your needs. We can also explain any supporting material you may need to provide as you apply for these programs. If for any reason you are denied, we also are experienced in the best appeals process with a high success rate.

Treats Disease/Condition

Uses

Dabrafenib may be used alone or in combination with another medication (trametinib) to treat a type of skin cancer (melanoma) that has spread or cannot be removed by surgery and has a certain type of abnormal "BRAF" gene. Dabrafenib belongs to a class of drugs known as kinase inhibitors. It works by slowing the growth of skin cancer cells.

How To Use

Read the Medication Guide provided by your pharmacist before you start taking dabrafenib and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take this medication by mouth as directed by your doctor, usually twice daily about 12 hours apart. Take this medication on an empty stomach, at least 1 hour before or 2 hours after meals. Swallow the capsules whole. Do not open, crush, chew, or break the capsules.

Side Effects

Hair loss, thickening of the outer layers of the skin, headache, swelling/peeling of feet/hands, and joint/muscle/back pain may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Dabrafenib may cause new skin cancers (including cutaneous squamous cell carcinoma) that can spread to other parts of the body. Tell your doctor right away if you have any skin changes, including: new wart, skin sore, change in size/color of a mole, skin bump that bleeds or does not heal. This medication may rarely make your blood sugar level rise, which can cause or worsen diabetes. Tell your doctor right away if you develop symptoms of high blood sugar, such as increased thirst and urination. If you already have diabetes, be sure to check your blood sugars regularly. Your doctor may need to adjust your diabetes medication, exercise program, or diet. In men, this medication can decrease sperm production, an effect that may lower male fertility. Consult your doctor for more details. Get medical help right away if you have any very serious side effects, including: eye pain/swelling/redness, vision changes (such as blurred vision, sensitivity to light), fast/irregular heartbeat, signs of infection (such as fever, chills, persistent sore throat, cough), dizziness/fainting, unusual dry mouth/thirst, signs of kidney problems (such as change in the amount of urine). Dabrafenib can commonly cause a rash that is usually not serious. However, you may not be able to tell it apart from a rash that could be a sign of a severe reaction. Therefore, tell your doctor right away if you develop any rash. Dabrafenib in combination with trametinib may rarely cause other serious side effects. Get medical help right away if you have any very serious side effects, including: signs of bleeding in the brain (such as severe headache, weakness on one side of the body, vision problems, slurred speech, seizures, or confusion), signs of stomach/intestinal bleeding (such as black/bloody stools, vomit that contains blood or looks like coffee grounds, or dizziness), sudden pain/swelling/redness (usually in the leg), chest pain, trouble breathing, new lumps/growth. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. This medication may decrease the effectiveness of hormonal birth control such as pills, patch, or ring. This could cause pregnancy. Discuss with your doctor or pharmacist if you should use additional reliable birth control methods while using this medication. Also tell your doctor if you have any new spotting or breakthrough bleeding, because these may be signs that your birth control is not working well. Other medications can affect the removal of dabrafenib from your body, which may affect how dabrafenib works. Examples include azole antifungals (such as itraconazole, ketoconazole), gemfibrozil, macrolide antibiotics (such as clarithromycin, erythromycin), nefazodone, St. John's wort, drugs used to treat seizures (such as carbamazepine, phenobarbital, phenytoin), among others. This medication can speed up the removal of other medications from your body, which may affect how they work. Examples include midazolam, warfarin, among others.

In Case of Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222.

In Case of Missed Dose

If you miss a dose, take it as soon as you remember. If it is within 6 hours of your next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.