Drug List


Drug Name

Ontak (Denileukin Diftitox)

Manufactured By

Eisai Inc.

Drug Savings

NPC's mission is your health. We recognize your need for help when you are applying for discount programs for your prescription medications. We consist of friendly and experienced advocates that not only know how these free and discount programs work, but are ready to help. We are available to take your call and answer any questions you may have as you search for the right program to fit your needs. We can also explain any supporting material you may need to provide as you apply for these programs. If for any reason you are denied, we also are experienced in the best appeals process with a high success rate.

Nationwide Prescription Connection (NPC) is an experienced advocacy service that helps connect patients to manufacturer provided free and discount programs. We can help the uninsured, under insured, those in the Medicare gap also known as the "doughnut hole", or even those needing help with expensive co-pays.  Our web site makes it easy for you to enter the medications you are taking, along with some basic patient information, and then finds the program that is right for you.

Treats Disease/Condition


Denileukin diftitox is used to treat patients with persistent or recurrent cutaneous T-cell lymphoma. The patient's lymphoma cells need to be a specific type -- they must have the high affinity component of the IL-2 receptor -- to be treated with this drug. This is generally confirmed by testing the lymphoma tissue before the drug is given.

How To Use

This medication is given by intravenous injection (IV), through a vein. The infusion will take 15 minutes or longer. The amount of denileukin diftitox that you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer or condition being treated. Your doctor will determine your dose and schedule.

Side Effects

The following side effects are common (occurring in greater than 30%) for patients taking denileukin diftitox: Hypersensitivity reaction during the infusion with symptoms such as low blood pressure, back pain, shortness of breath (see allergic reactions). Fever/Chills (usually occurs during or soon after the infusion). Nausea and vomiting. Blood test abnormalities (low albumin level, hypoalbuminemia). Liver problems (elevated liver enzymes; transaminase). Weakness. Swelling (usually of hands and feet). Infection. Pain. Low blood pressure (hypotension). Poor appetite. Rash. These side effects are less common side effects (occurring in about 10-29%) of patients receiving denileukin diftitox: Diarrhea Shortness of breath Headache Chest pain Cough Dizziness Itching Pharyngitis or Rhinitis (inflammation of the throat or nose) (see cold symptoms). Low Red blood cell count. Your red blood cells may temporarily decrease. This can put you at increased risk for anemia. Numbness and tingling of hands and feet. Blood test abnormalities (low calcium level, low albumin level). Muscle pain Weight loss Rapid heart rate (see heart problems) Anxiety or nervousness Sweating (see skin problems) Blood in the urine (see bladder problems) Cloudy urine (see kidney problems) A serious side effect of denileukin diftitox is "capillary leak syndrome" or "vascular leak syndrome." Capillary leak syndrome is a potentially serious disease in which fluids within the vascular system (veins and capillaries) leaks into the tissue outside the bloodstream. This results in low blood pressure and poor blood flow to the internal organs. Capillary leak syndrome is characterized by the presence of 2 or more of the following 3 symptoms; low blood pressure, swelling, and low levels of protein in the blood. Your doctor will monitor these things carefully while you are taking denileukin diftitox. You should notify your doctor immediately if you notice dizziness (especially when changing position), sudden swelling or rapid weight gain, little or no urine output (for 8-12 hours), shortness of breath, difficulty breathing, irregular heart beats, or chest pain. If this syndrome occurs, it will likely be delayed, within about 2 weeks of treatment.

Drug Interactions

No formal drug-drug interaction studies have been conducted with Ontak

In Case of Overdose

Seek imediate medical attention Doses of approximately twice the recommended dose (31 mcg/kg/day) resulted in moderate-to-severe nausea, vomiting, fever, chills and/or persistent asthenia.

In Case of Missed Dose

MISSED DOSE: Consult your pharmacist.


STORAGE: Consult your pharmacist.