Olysio

Drug List

Olysio

Drug Name

Olysio (Simeprevir)

Manufactured By

Johnson & Johnson Healthcare Products, Division of

Drug Savings

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Treats Disease/Condition

Uses

Simeprevir is an antiviral drug used in combination with other medications (such as sofosbuvir or peginterferon/ribavirin) to treat chronic (long-lasting) hepatitis C, a viral infection of the liver. Simeprevir belongs to a class of drugs known as protease inhibitors. It works by reducing the amount of hepatitis C virus in your body, which may help your liver recover. Chronic hepatitis C infection can cause serious liver problems such as scarring (cirrhosis) or liver cancer. This combination treatment reduces the amount of hepatitis C virus in the body and helps the body's immune system fight the infection. It is not known if this treatment can prevent you from passing the virus to others. Do not share needles, and practice "safe sex" (including the use of latex condoms) to lower the risk of passing the virus to others. Simeprevir must be used in combination treatment to have the best effect. Taking it by itself can make your treatment less effective.

How To Use

Read the Patient Information Leaflet if available from your pharmacist before you start taking simeprevir and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Also read the drug information for your other antiviral medication(s). Take this medication by mouth with food as directed by your doctor, usually once daily. Swallow the capsules whole. Simeprevir works best when the amount of medicine in your body is kept at a constant level. Therefore, take this drug at evenly spaced intervals. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.

Side Effects

Nausea or skin itching may occur. If either of these effects persists or worsens, tell your doctor or pharmacist promptly. Simeprevir can commonly cause a rash or skin reaction to sunlight that is usually not serious, especially during the first 4 weeks of treatment. However, you may not be able to tell it apart from a rare rash that could be a sign of a severe reaction. Therefore, tell your doctor right away if you develop any rash, especially a rash with blisters/swelling. However, do not stop taking simeprevir if you develop a rash unless directed by your doctor. (See also Precautions section.) Although this medication is used to treat hepatitis C, it may cause severe liver disease in some people, especially people with other liver problems. Tell your doctor right away if you get new or worsening symptoms of liver disease, including: persistent nausea/vomiting, severe stomach/abdominal pain, yellowing eyes/skin, loss of appetite, dark urine. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Other medications can affect the removal of simeprevir from your body, which may affect how simeprevir works. Examples include azole antifungals (such as ketoconazole, itraconazole), cyclosporine, dexamethasone, macrolide antibiotics (such as erythromycin, clarithromycin), HIV NNRTIs (such as efavirenz, etravirine, nevirapine, delavirdine), HIV protease inhibitors (such as atazanavir, ritonavir), rifamycins (such as rifabutin, rifampin), St. John's wort, telithromycin, certain drugs used to treat seizures (such as carbamazepine, phenobarbital, phenytoin), among others.

In Case of Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222.

In Case of Missed Dose

If you miss a dose and it is more than 12 hours until your next dose, take it as soon as you remember. If it is less than 12 hours until your next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.