Emend

Drug List

Emend

Drug Name

Emend (Aprepitant)

Manufactured By

Merck & Company, Inc

Drug Savings

NPC's mission is your health. We recognize your need for help when you are applying for discount programs for your prescription medications. We consist of friendly and experienced advocates that not only know how these free and discount programs work, but are ready to help. We are available to take your call and answer any questions you may have as you search for the right program to fit your needs. We can also explain any supporting material you may need to provide as you apply for these programs. If for any reason you are denied, we also are experienced in the best appeals process with a high success rate.

NPC's mission is your health. We recognize your need for help when you are applying for discount programs for your prescription medications. We consist of friendly and experienced advocates that not only know how these free and discount programs work, but are ready to help. We are available to take your call and answer any questions you may have as you search for the right program to fit your needs. We can also explain any supporting material you may need to provide as you apply for these programs. If for any reason you are denied, we also are experienced in the best appeals process with a high success rate.

Treats Disease/Condition

Uses

Aprepitant is used with other medications to help prevent nausea and vomiting caused by cancer drug treatment (chemotherapy). This medication is also used to prevent nausea and vomiting after surgery. Aprepitant works by blocking one of the body's natural substances (substance P/neurokinin 1) that causes vomiting. This medication will not treat nausea or vomiting that has already started. Ask your doctor what you should do if you already have nausea or vomiting.

How To Use

Read the Patient Information Leaflet if available from your pharmacist before you start taking aprepitant and each time you get a refill. If you are taking the liquid form of this medication, read the Instructions for Use sheet for directions on the proper use of this medication. If you have any questions, ask your doctor or pharmacist. Take this medication by mouth with or without food as directed by your doctor. If you are taking capsules, swallow the capsules whole. To prevent nausea and vomiting caused by cancer chemotherapy, take the first dose as directed by your doctor, usually 1 hour before the start of chemotherapy. For the next 2 days, continue to take a dose once daily 1 hour before the start of treatment if you are getting chemotherapy that day. If you are not getting any chemotherapy, then take the dose once daily in the morning. If you are taking this medication to prevent nausea and vomiting after surgery, take one dose of 40 milligrams as directed by your doctor, usually within 3 hours before the start of surgery. The dosage is based on your medical condition (depending on whether you are taking this medication before cancer chemotherapy or surgery), age, and response to treatment. In children, the dosage is also based on weight. It is important to follow your doctor's instructions for when to take each dose, how long to keep taking it, and the strength (number of milligrams) of each dose. If you have any questions, ask your doctor or pharmacist.

Side Effects

Tiredness or hiccups may occur. If either of these effects lasts or gets worse, tell your doctor or pharmacist promptly. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Other medications can affect the removal of aprepitant from your body, which may affect how aprepitant works. Examples include azole antifungals (such as itraconazole, ketoconazole), diltiazem, macrolide antibiotics (such as clarithromycin, erythromycin), nefazodone, HIV protease inhibitors (such as ritonavir, nelfinavir), rifamycins (such as rifampin, rifabutin), St. John's wort, certain anti-seizure medicines (such as carbamazepine, phenytoin), among others. Aprepitant can both speed up or slow down the removal of other medications from your body, which may affect how they work. Examples of affected drugs include flibanserin, pimozide, among others. If you take warfarin, this drug may affect how well warfarin works in your body. Your doctor should test your blood during the 2 weeks after your aprepitant treatment to measure how well warfarin is working. This medication may decrease the effectiveness of hormonal birth control such as pills, patch, or ring. This could cause pregnancy. Discuss with your doctor or pharmacist if you should use additional reliable birth control methods while using this medication and for 1 month after stopping this medication. Also tell your doctor if you have any new spotting or breakthrough bleeding, because these may be signs that your birth control is not working well. Aprepitant is very similar to fosaprepitant. Do not use fosaprepitant while using aprepitant.

In Case of Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222.

In Case of Missed Dose

For the best possible benefit, it is important to take each scheduled dose of this medication as directed. If you miss a dose, contact your doctor or pharmacist right away to establish a new dosing schedule. Do not double the dose to catch up.

Storage

Store the capsules at room temperature away from light and moisture. Store the liquid in the refrigerator and discard any unused liquid after 72 hours. Do not freeze. When ready to use, the liquid form of this medication may be stored at room temperature for up to 3 hours. Do not store in the bathroom. Keep all medications away from children and pets.