Drug List


Drug Name

DTIC-Dome (Dacarbazine)

Manufactured By

Bayer Healthcare Pharmaceuticals

Drug Savings

Nationwide Prescription Connection (NPC) is an experienced advocacy service that helps connect patients to manufacturer provided free and discount programs. We can help the uninsured, under insured, those in the Medicare gap also known as the "doughnut hole", or even those needing help with expensive co-pays.  Our web site makes it easy for you to enter the medications you are taking, along with some basic patient information, and then finds the program that is right for you.

NPC's mission is your health. We recognize your need for help when you are applying for discount programs for your prescription medications. We consist of friendly and experienced advocates that not only know how these free and discount programs work, but are ready to help. We are available to take your call and answer any questions you may have as you search for the right program to fit your needs. We can also explain any supporting material you may need to provide as you apply for these programs. If for any reason you are denied, we also are experienced in the best appeals process with a high success rate.

Treats Disease/Condition


Dacarbazine is used for metastatic malignant melanoma, Hodgkin's disease, soft tissue sarcomas, neuroblastoma, fibrosarcomas, rhabdomyosarcoma, islet cell carcinoma, and medullary carcinoma of the thyroid. Note: If a drug has been approved for one use, physicians may elect to use this same drug for other problems if they believe it may be helpful.

How To Use

Dacarbazine is given into a vein (intravenously, IV). Dacarbazine is an irritant. An irritant is a chemical that can cause inflammation of the vein through which it is given. If the medication escapes from the vein it can cause tissue damage. The nurse or doctor who gives this medication must be carefully trained. If you experience pain or notice redness or swelling at the IV site while you are receiving dacarbazine, alert your health care professional immediately. The amount of dacarbazine that you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer or condition being treated. Your doctor will determine your dose and schedule.

Side Effects

The following side effects are common (occurring in greater than 30%) for patients taking dacarbazine: Local pain, burning sensation and irritation at the needle site during the infusion. Low blood counts. Your white and red blood cells and platelets may temporarily decrease. This can put you at increased risk for infection, anemia and/or bleeding. Onset: 5 - 7 days , Nadir: 7 - 10 days, Recovery: 21 - 28 days , Nausea and vomiting. Poor appetite. Elevation of blood liver enzymes. These side effects are less common side effects (occurring in about 10-29%) of patients receiving dacarbazine: Flu-like symptoms (chills, fever, aches). Numbness or tingling in the hands or feet. Sensitivity to the sun - may get sunburned quickly (photosensitivity) (see skin reactions).Delayed effects:There is a slight risk of developing a blood cancer such as leukemia after taking dacarbazine. Talk to your doctor about this risk. Contact your health care provider immediately, day or night, if you should experience any of the following symptoms:Fever of 100.4° F (38° C) or higher, chills (possible signs of infection).The following symptoms require medical attention, but are not an emergency. Contact your health care provider within 24 hours of noticing any of the following:Nausea (interferes with ability to eat and unrelieved with prescribed medication).Vomiting (vomiting more than 4-5 times in a 24 hour period) Unusual bleeding or bruising Black or tarry stools, or blood in your stools, Blood in the urine, Extreme fatigue (unable to carry on self-care activities), Pain, redness or swelling at IV site

Drug Interactions

Severe Interactions of DTIC-Dome intravenous: These medications are not usually taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. SELECTED IMMUNOSUPPRESSANTS/TALIMOGENE LAHERPAREPVEC SELECTED IMMUNOSUPPRESSIVE AGENTS/LIVE VACCINES; LIVE BCG IMMUNOSUPPRESSIVES; IMMUNOMODULATORS/EFALIZUMAB; NATALIZUMAB Serious Interactions of DTIC-Dome intravenous: These medications may interact and cause very harmful effects. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. IMMUNOSUPPRESSIVES; IMMUNE-MODULATORS/FINGOLIMOD SELECTED MYELOSUPPRESSIVE AGENTS/CLOZAPINE SELECTED MYELOSUPPRESSIVE AGENTS/DEFERIPRONE

In Case of Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222.

In Case of Missed Dose

For the best possible benefit, it is important to receive each scheduled dose of this medication as directed. If you miss a dose, contact your doctor or pharmacist right away to establish a new dosing schedule.


Not applicable. This medication is given in a clinic and will not be stored at home.