Darzalex

Drug List

Darzalex

Drug Name

Darzalex (Daratumumab)

Manufactured By

Johnson & Johnson Healthcare Products, Division of

Drug Savings

Nationwide Prescription Connection (NPC) is an experienced advocacy service that helps connect patients to manufacturer provided free and discount programs. We can help the uninsured, under insured, those in the Medicare gap also known as the "doughnut hole", or even those needing help with expensive co-pays.  Our web site makes it easy for you to enter the medications you are taking, along with some basic patient information, and then finds the program that is right for you.

Nationwide Prescription Connection (NPC) is an experienced advocacy service that helps connect patients to manufacturer provided free and discount programs. We can help the uninsured, under insured, those in the Medicare gap also known as the "doughnut hole", or even those needing help with expensive co-pays.  Our web site makes it easy for you to enter the medications you are taking, along with some basic patient information, and then finds the program that is right for you.

Treats Disease/Condition

Uses

Darzalex™ (daratumumab, Janssen/Genmab) is a monoclonal antibody. It is approved for use in the treatment of patients with multiple myeloma who have received at least three prior lines of therapy, including a proteasome inhibitor and an immunomodulatory agent (IMiD), or who are refractory to both a proteasome inhibitor and an IMiD.

How To Use

Darzalex™ (daratumumab, Janssen/Genmab) is given as an intravenous (IV) infusion into a vein. It is typically given at a dose of 16 mg/kg of body weight and is administered weekly during Weeks 1 through 8, every two weeks during Weeks 9 through 24, and then every 4 weeks until disease progression. Before receiving Darzalex, patients receive premedication with antihistamines, fever-reducing agents, and steroids to reduce the risk of infusion reactions. Following the infusion of Darzalex, patients also receive a steroid to reduce the risk of delayed infusion reactions. Patients receiving Darzalex also receive medication to prevent shingles, a viral infection that causes a painful rash and is due to a reactivation of the virus that causes chickenpox (herpes zoster virus).

Side Effects

In clinical studies, the most common side effects seen with Darzalex™ (daratumumab, Janssen/Genmab) included: Infusion reactions Fatigue Nausea Back pain Fever Cough Upper respiratory infection The most common serious side effects included low lymphocyte, red blood cell, neutrophil, and platelet counts. In clinical trials, severe infusion reactions, such as spasms of the muscles in the major airways of the lung, low oxygen levels, difficulty breathing, and high blood pressure, have been seen with Darzalex. For this reason, patients receive premedication with antihistamines, fever-reducing agents, and steroids before infusion of Darzalex to reduce the risk of infusion reactions. Following the infusion of Darzalex, patients also receive a steroid to reduce the risk of delayed infusion reactions. How are side effects of Darzalex managed? Patients who experience an infusion reaction will have their Darzalex infusion stopped and their symptoms treated. After symptoms resolve, the infusion may be resumed at a slower rate. Darzalex will be discontinued in patients who experience a life-threatening infusion reaction or multiple severe reactions.

Drug Interactions

Other drugs may interact with daratumumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using

In Case of Overdose

Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

In Case of Missed Dose

Call your doctor for instructions if you miss an appointment for your daratumumab injection.

Storage