Drug List


Drug Name

Brineura (Cerliponase alpa)

Manufactured By

BioMarin Pharmaceutical, Inc.

Drug Savings

Nationwide Prescription Connection (NPC) is an experienced advocacy service that helps connect patients to manufacturer provided free and discount programs. We can help the uninsured, under insured, those in the Medicare gap also known as the "doughnut hole", or even those needing help with expensive co-pays.  Our web site makes it easy for you to enter the medications you are taking, along with some basic patient information, and then finds the program that is right for you.

NPC's mission is your health. We recognize your need for help when you are applying for discount programs for your prescription medications. We consist of friendly and experienced advocates that not only know how these free and discount programs work, but are ready to help. We are available to take your call and answer any questions you may have as you search for the right program to fit your needs. We can also explain any supporting material you may need to provide as you apply for these programs. If for any reason you are denied, we also are experienced in the best appeals process with a high success rate.

Treats Disease/Condition


Indicated to slow the loss of ambulation in symptomatic pediatric patients 3 years of age and older with late infantile neuronal ceroid lipofuscinosis type 2 (CLN2), also known as tripeptidyl peptidase 1 (TPP1) deficiency.

How To Use

The recommended dosage of Brineura in pediatric patients 3 years of age and older is 300 mg administered once every other week by intraventricular infusion. Administer Brineura first followed by infusion of the Intraventricular Electrolytes each at an infusion rate of 2.5 mL/hr. The complete Brineura infusion, including the required infusion of Intraventricular Electrolytes, is approximately 4.5 hours. Pre-treatment of patients with antihistamines with or without antipyretics or corticosteroids is recommended 30 to 60 minutes prior to the start of infusion.

Side Effects

Common side effects of Brineura include: * fever, * ECG abnormalities, * increased or decreased cerebrospinal fluid (CSF) protein, * vomiting, * seizures, * hypersensitivity, * blood clotting, * headache, * irritability, * increased white blood cell count (pleocytosis), * device-related infection, * slow heart rate, * feeling jittery, and * low blood pressure (hypotension).

Drug Interactions

None information at this time.

In Case of Overdose

Given in a clinical setting, should not be risk of over dosing.

In Case of Missed Dose

Talk to your healthcare provider if you are unable to keep your infusion appointment


Brineura (cerliponase alfa) Injection and Intraventricular Electrolytes Injection: Store upright in a freezer (‑25°C to ‑15°C) in original carton to protect from light. Administration Kit for use with Brineura: Store in original carton separately from Brineura. Do not freeze.