Drug List


Drug Name

Anafranil (Clomipramine)

Manufactured By

Mallinckrodt Inc.

Drug Savings

Nationwide Prescription Connection (NPC) is an experienced advocacy service that helps connect patients to manufacturer provided free and discount programs. We can help the uninsured, under insured, those in the Medicare gap also known as the "doughnut hole", or even those needing help with expensive co-pays.  Our web site makes it easy for you to enter the medications you are taking, along with some basic patient information, and then finds the program that is right for you.

NPC's mission is your health. We recognize your need for help when you are applying for discount programs for your prescription medications. We consist of friendly and experienced advocates that not only know how these free and discount programs work, but are ready to help. We are available to take your call and answer any questions you may have as you search for the right program to fit your needs. We can also explain any supporting material you may need to provide as you apply for these programs. If for any reason you are denied, we also are experienced in the best appeals process with a high success rate.

Treats Disease/Condition


DRUG CLASS AND MECHANISM: Clomipramine (Anafranil) is a psychotropic agent used to treat obsessive-compulsive disorder (OCD). Clomipramine shares structural similarities with a class of antidepressants known as tricyclic antidepressants (TCAs). The exact mechanism by which clomipramine exerts its therapeutic benefits is not fully understood. However, similar to other TCAs, clomipramine is thought to enhance the actions of norepinephrine and serotonin (chemical neurotransmitters in the brain that nerves use to communicate with one another) by blocking their reuptake and prolonging their activity. Clomipramine also has anticholinergic properties which means it blocks the action of another neurotransmitter, acetylcholine. This increases the risk for certain side effects. It also has weak antihistamine properties which appear to play a role in the mild sedative effects observed with use. Clomipramine was approved by the US FDA for the treatment of OCD in 1991.Although not approved by the FDA for these indications, clomipramine is used off-label for the treatment of major depression, panic attacks, anxiety disorders, and premature ejaculation

How To Use

For the treatment of obsessive-compulsive disorder in adults: Treatment is generally started with 25 mg by mouth once daily. Dosage may be gradually increased by 25 mg increments every 3-4 days up to a total daily dose of 100 mg by the end of 2 weeks. Thereafter, the dose may be gradually increased over a period of several weeks to 250 mg. Total daily dose is usually given in divided doses with meals to decrease the occurrence of gastrointestinal (stomach related) side effects. Once tolerated, the total dose may be given at bedtime. For the treatment of obsessive-compulsive disorder in children and adolescents: For children between the ages of 10 and 17, the usual recommended starting dose is 25 mg per day. Dosage may be increased in 25 mg increments every 3-4 days as tolerated up to 100 mg/day or 3 mg/kg/day, whichever is the smaller, over the first 2 weeks. Thereafter, dosage may be increased slowly as necessary to a daily maximum of 3 mg/kg/day or 200 mg/day, whichever is smaller. The safety and effectiveness of clomipramine treatment has not been evaluated in children less than 10 years of age.

Side Effects

IDE EFFECTS: The most common side effects associated with the use of clomipramine include: upset stomach, dry mouth, constipation, nausea, heartburn, anorexia, tremor, dizziness, tiredness, nervousness, sexual dysfunction, weight gain, low blood pressure, sweating, respiratory problems, and visual changes.

Drug Interactions

Patients starting treatment with clomipramine should consult with their doctor or pharmacist to find out if any of their current medications or supplements have any drug interactions with clomipramine. Also, patients receiving treatment with clomipramine should always consult with their doctor before starting treatment with any new medications. Clomipramine generally is not recommended to be used with other tricyclic antidepressants or related cyclic antidepressants. Co-administration with medications that share similar properties increases the risk for side effects. Examples of similar antidepressants are amoxapine, imipramine (Tofranil), and desipramine (Norpramin).

In Case of Overdose

Seek medical attention

In Case of Missed Dose

take as soon as remember it as long as it is at least 12 hours from next dose


Tablets should be stored at room temperature, between 15 C to 30 C (59 F to 86 F). As with all medications, clomipramine tablets should be kept out of the reach of children and pets.