Afinitor Disperz

Drug List

Afinitor Disperz

Drug Name

Afinitor Disperz (Everolimus)

Manufactured By

Abbott Laboratories

Drug Savings


Nationwide Prescription Connection (NPC) is an experienced advocacy service that helps connect patients to manufacturer provided free and discount programs. We can help the uninsured, under insured, those in the Medicare gap also known as the "doughnut hole", or even those needing help with expensive co-pays.  Our web site makes it easy for you to enter the medications you are taking, along with some basic patient information, and then finds the program that is right for you.


NPC's mission is your health. We recognize your need for help when you are applying for discount programs for your prescription medications. We consist of friendly and experienced advocates that not only know how these free and discount programs work, but are ready to help. We are available to take your call and answer any questions you may have as you search for the right program to fit your needs. We can also explain any supporting material you may need to provide as you apply for these programs. If for any reason you are denied, we also are experienced in the best appeals process with a high success rate.

Treats Disease/Condition

Uses

Everolimus is a cancer medicine that interferes with the growth of cancer cells and slows their spread in the body. The Afinitor brand of everolimus is used to treat certain types of kidney cancer, breast cancer, or brain tumor. Afinitor is also used to treat certain types of advanced or progressive tumors of the stomach, intestines, or pancreas. Afinitor is usually given after other treatments have been tried without success. Afinitor is also used to treat non-cancerous (benign) tumors of the kidney in people with a certain genetic condition called tuberous sclerosis complex.

How To Use

Read the Patient Information Leaflet if available from your pharmacist before you start taking everolimus and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Do not change dosage forms of this medication without checking with your doctor or pharmacist. Take this medication by mouth as directed by your doctor, usually once daily. You may take this medication with or without food, but it is important to choose one way and take this medication the same way with every dose. Do not swallow the tablet whole. This medication must be dispersed in water before swallowing. If another person is helping you prepare this medication, he/she should wear gloves while preparing each dose to avoid possible contact with everolimus. Do not disperse more than 10 milligrams total at a time. You may use an oral syringe or a drinking glass (see instructions in the package). If you are using an oral syringe, place the medication into a 10-milliliter syringe. Do not break or crush the tablet(s). Draw 1 teaspoon (5 milliliters) of water into the syringe. Place the filled syringe into a container (tip up) for 3 minutes to allow the tablet(s) to disperse. Gently swirl the syringe 5 times before taking the medication. To make sure you have taken the whole dose, draw another teaspoon (5 milliliters) of water into the syringe, swirl, and take the rest of the mixture. If you are using a drinking glass, place the medication in a glass with about 5 teaspoons (25 milliliters) of water. Do not use other liquids. Do not break or crush the tablet(s). After 3 minutes, stir the mixture gently with a spoon, then drink all of the mixture right away. To make sure you have taken the whole dose, add another 5 teaspoons (25 milliliters) of water to the glass to rinse it, and drink all the rinse water. Take this medication within 60 minutes of mixing. The dosage is based on your medical condition, body size, response to treatment, laboratory tests, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor or pharmacist says you may do so safely. Grapefruit can increase the chance of side effects with this medicine. Ask your doctor or pharmacist for more details.

Side Effects

Diarrhea, nausea/vomiting, decreased appetite, weight loss, changes in taste, nosebleeds, dry skin, dizziness, and headache may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Pain or sores in the mouth and throat may occur. Brush your teeth carefully/gently and avoid using mouthwash that contains alcohol, iodine, peroxide, or thyme. Rinse your mouth frequently with cool water mixed with baking soda or salt. It may also be best to eat soft, moist foods. Temporary hair loss may occur. Normal hair growth should return after treatment has ended. Tell your doctor right away if you have any serious side effects, including: swelling hands/ankles/feet, missed/heavy/painful periods, easy bruising/bleeding, unusual tiredness, mental/mood changes (such as anxiety, aggression), wound problems (such as slowed wound healing). Everolimus has rarely caused very serious (possibly fatal) kidney problems. Tell your doctor right away if you develop signs of kidney problems, such as a change in the amount of urine. This medication may rarely make your blood sugar level rise, which can cause or worsen diabetes. Tell your doctor right away if you develop symptoms of high blood sugar, such as increased thirst and urination. If you already have diabetes, be sure to check your blood sugars regularly. Your doctor may need to adjust your diabetes medication, exercise program, or diet. This medication may cause your cholesterol/triglycerides to increase. You may need to have your cholesterol/triglycerides checked periodically and/or take another medication to control your cholesterol/triglycerides. This medication may lower your ability to fight infections. This may make you more likely to get a serious (rarely fatal) infection or make any infection you have worse. Tell your doctor right away if you have any signs of infection (such as fever, chills, persistent sore throat, cough). This medication has caused very serious (rarely fatal) lung problems. Get medical help right away if you have symptoms of lung problems, such as shortness of breath, chest pain. Everolimus may rarely cause serious (possibly fatal) liver disease in people who have hepatitis B virus. Get medical help right away if you have any symptoms of liver damage, including: dark urine, persistent nausea/vomiting/loss of appetite, stomach/abdominal pain, yellow eyes/skin. This medication may increase your risk of getting a rare but very serious (sometimes fatal) brain infection (progressive multifocal leukoencephalopathy-PML). Get medical help right away if any of these rare but very serious side effects occur: clumsiness, loss of coordination, weakness, sudden change in your thinking (such as confusion, difficulty concentrating), difficulty moving your muscles, problems with speech, seizure, vision changes. This medication may affect male and female fertility. Consult your doctor for more details. Everolimus can commonly cause a mild rash that is usually not serious. However, you may not be able to tell it apart from a rare rash that could be a sign of a severe allergic reaction. Therefore, get medical help right away if you develop any rash. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Some products that may interact with this drug include: other drugs that weaken the immune system/increase the risk of infection (such as natalizumab, rituximab), ACE inhibitors (such as captopril, lisinopril). Other medications can affect the removal of everolimus from your body, which may affect how everolimus works. Examples include azole antifungals (such as itraconazole, ketoconazole), cobicistat, macrolide antibiotics (such as clarithromycin, erythromycin), nefazodone, HIV protease inhibitors (such as atazanavir, indinavir), St. John's wort, telithromycin, among others.

In Case of Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222

In Case of Missed Dose

If you miss a dose, take it as soon as you remember unless it is more than 6 hours after the time you usually take the dose. In that case, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. Discard mixture if not taken after 60 minutes.