Drug List


Drug Name

Adlyxin (Lixisenatide)

Manufactured By

Sanofi-Aventis U.S. LLC

Drug Savings

Nationwide Prescription Connection (NPC) is an experienced advocacy service that helps connect patients to manufacturer provided free and discount programs. We can help the uninsured, under insured, those in the Medicare gap also known as the "doughnut hole", or even those needing help with expensive co-pays.  Our web site makes it easy for you to enter the medications you are taking, along with some basic patient information, and then finds the program that is right for you.

NPC's mission is your health. We recognize your need for help when you are applying for discount programs for your prescription medications. We consist of friendly and experienced advocates that not only know how these free and discount programs work, but are ready to help. We are available to take your call and answer any questions you may have as you search for the right program to fit your needs. We can also explain any supporting material you may need to provide as you apply for these programs. If for any reason you are denied, we also are experienced in the best appeals process with a high success rate.

Treats Disease/Condition


Lixisenatide is an injectable drug that reduces the level of sugar (glucose) in the blood. It is used for the treatment type 2 diabetes. Lixisenatide belongs in a class of drugs called incretin mimetics because these drugs mimic the effects of incretins. Incretins, such as human-glucagon-like peptide-1 (GLP-1), are hormones that are produced and released into the blood by the intestine in response to food. GLP-1 increases the secretion of insulin from the pancreas, slows absorption of glucose from the gut, and reduces the action of glucagon. (Glucagon is a hormone that increases glucose production by the liver.) All three of these actions reduce levels of glucose in the blood. In addition, GLP-1 reduces appetite. Lixisenatide is a synthetic (man-made) hormone that resembles and acts like GLP-1. In studies, lixisenatide treated patients achieved lower blood glucose levels and experienced weight loss.

How To Use

The recommended starting dose of Adlyxin is 10 mcg injected under the skins (subcutaneously) once daily for 14 days. The dose should be increased on day 15 to the maintenance dose of 20 mcg once daily.

Side Effects

Common side effects of include:Nausea, Vomiting, Diarrhea, Headache, Diarrhea, Dizziness, Hypoglycemia Other possible side effects of include:Indigestion , Constipation, Upper abdominal pain, Abdominal distension, Injection site reactions (pain, redness, itching) Possible serious side effects of include:Severe allergic reactions (anaphylaxis, angioedema [hives]), Pancreatitis, Acute kidney failure, Antibodies to lixisenatide ,

Drug Interactions

Adlyxin slows down transit of food and drugs through the intestine and, therefore, may reduce the absorption of drugs that are taken by mouth. Caution should be used when combining Adlyxin with oral medications that have a narrow therapeutic ratio or that require careful monitoring. If these medications are to be taken with food they should be taken with a meal or snack when Adlyxin is not administered. Oral medications such as antibiotics, or medications, for example acetaminophen (Tylenol) whose effects shouldn't be delayed should be taken at least 1 hour before Adlyxin injection. Oral contraceptives should be taken at least 1 hour before Adlyxin administration or at least 11 hours after an injection of Adlyxin. Combining Adlyxin with insulin or drugs that stimulate release of insulin, for example, glyburide (Micronase, Diabeta, Glynase, Prestab) may increase the occurrence of low blood sugar (hypoglycemia). The dose of insulin or the insulin release stimulating drug should be reduced.

In Case of Overdose

During clinical studies, doses up to 30 mcg of lixisenatide twice daily (3 times the daily recommended dose) were administered to type 2 diabetic patients in a 13-week study. The 30 mcg dose of lixisenatide is not an approved dose. An increased incidence of gastrointestinal disorders was observed. In case of overdose, appropriate supportive treatment should be initiated according to the patient’s clinical signs and symptoms.

In Case of Missed Dose


Adlyxin pen should be kept in the package to protect it from light and it should be stored in a refrigerator at 2 C to 8 C (36 F to 46 F) prior to use. It should not be frozen. After first use, it should be stored below 30 C (86 F). The pen cap should be replaced after each use to protect it from light. The pen should discarded 14 days after first use.