Drug List


Drug Name

Activase (Alteplase (rDNA))

Manufactured By

Genentech, Inc.

Drug Savings

NPC's mission is your health. We recognize your need for help when you are applying for discount programs for your prescription medications. We consist of friendly and experienced advocates that not only know how these free and discount programs work, but are ready to help. We are available to take your call and answer any questions you may have as you search for the right program to fit your needs. We can also explain any supporting material you may need to provide as you apply for these programs. If for any reason you are denied, we also are experienced in the best appeals process with a high success rate.

Nationwide Prescription Connection (NPC) is an experienced advocacy service that helps connect patients to manufacturer provided free and discount programs. We can help the uninsured, under insured, those in the Medicare gap also known as the "doughnut hole", or even those needing help with expensive co-pays.  Our web site makes it easy for you to enter the medications you are taking, along with some basic patient information, and then finds the program that is right for you.

Treats Disease/Condition


Treating blood clots in the lungs. It is also used to improve heart function and survival following a heart attack. It is also used to improve recovery and reduce disability in certain patients who have had a stroke. It may also be used for other conditions as determined by your doctor.

How To Use

Activase is given as an injection at your doctor's office, hospital, or clinic. If you miss a dose of Activase, contact your doctor right away. Ask your health care provider any questions you may have about how to use Activas

Side Effects

COMMON side effects have been reported with Activase. Seek medical attention right away if any of these SEVERE side effects occur: Severe allergic reactions (rash; hives; itching; difficulty breathing or swallowing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue); change in color of your fingers or toes; changes in vision; chest pain or pressure; confusion; fainting; one-sided weakness; purple skin color; severe dizziness or headache; severe muscle aches or pain; severe stomach pain; speech problems or changes; symptoms of bleeding (eg, vomiting blood or vomit that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; unusual vaginal bleeding; bruises without a reason or that get bigger; any bleeding that is severe or that you cannot stop); symptoms of kidney problems (eg, not able to pass urine, change in how much urine is passed, blood in the urine, a big weight gain); symptoms of pancreatitis (eg, severe stomach or back pain, with or without nausea or vomiting).

Drug Interactions

Abciximab, anticoagulants (eg, warfarin, heparin), antiplatelet medicine (eg, clopidogrel), aspirin, or dipyridamole because the risk of bleeding may be increased Angiotensin-converting enzyme (ACE) inhibitors (eg, lisinopril) because the risk of serious side effects, such as severe swelling or trouble breathing, may be increased Nitrates (eg, nitroglycerin, isosorbide dinitrate) because the effectiveness of Activase may be decreased

In Case of Overdose

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

In Case of Missed Dose

If you miss a dose of Activase, contact your doctor right away.


Activase is handled and stored by a health care provider. You will not store it at home. Keep all medicines out of the reach of children and away from pets.